Columbus is a city in Colorado County in southeastern Texas, United States, 74 miles west of Houston. The population was 3,655 as of the 2010 census. It is the county seat of Colorado County and is located on the Colorado River. The Colorado County Courthouse is listed on the National Register of Historic Places.The town motto, coined by James Harbert Wooten, Jr., M.D., is "City of Live Oaks and Live Folks". Columbus is the home of a Santa Claus Museum, based on the collection of Mary Elizabeth Hopkins.